At least 17 people were killed and dozens injured across Egypt on Friday, as security forces confronted Muslim Brotherhood supporters.

The Health Ministry said there were 10 deaths in Cairo, three in Fayoum, two in Alexandria, and one each in Ismaliya and Minya in upper Egypt.

At least 258 people have been arrested, according to police.

Demonstrators chanted, “Down with military rule”. to protest against the July 3 coup that removed President Mohamed Morsi and the subsequent crackdown that has detained thousands of people, including Brotherhood leaders, and killed hundreds.

Cairo’s main squares were sealed off by security forces using barbed wire and military vehicles.

The military-backed interim Government, proclaiming a “road map” to democratic rule, has scheduled a vote on a new Constitution for later this month.